Modeling of copy number variability in Pichia pastoris

Modeling of copy number variability in Pichia pastoris

Development of continuous biopharmaceutical manufacturing processes is an area of active research. This study considers the long-term transgene copy number stability of Pichia pastoris in continuous bioreactors. We propose a model of copy number loss that quantifies population heterogeneity. An anal...

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Bibliographic Details
Main Authors: Lu, Amos E., Maloney, Andrew J., Dalvie, Neil C., Brady, Joseph R., Love, Kerry R., Love, J. Christopher, Braatz, Richard D.
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: Wiley 2022
Online Access:https://hdl.handle.net/1721.1/140439

Internet

https://hdl.handle.net/1721.1/140439

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