High-pH structure of EmrE reveals the mechanism of proton-coupled substrate transport

<jats:title>Abstract</jats:title><jats:p>The homo-dimeric bacterial membrane protein EmrE effluxes polyaromatic cationic substrates in a proton-coupled manner to cause multidrug resistance. We recently determined the structure of substrate-bound EmrE in phospholipid bilayers by mea...

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Bibliographic Details
Main Authors: Shcherbakov, Alexander A, Spreacker, Peyton J, Dregni, Aurelio J, Henzler-Wildman, Katherine A, Hong, Mei
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2022
Online Access:https://hdl.handle.net/1721.1/141081