Di- tert -butyl Phosphonate Route to the Antiviral Drug Tenofovir
© Di-tert-butyl oxymethyl phosphonates were investigated regarding their suitability for preparing the active pharmaceutical ingredient tenofovir (PMPA). First, an efficient and simple access to the crystalline di-tert-butyl(hydroxymethyl)phosphonate was developed. O-Mesylation gave high yields of...
Main Authors: | , , , , |
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Other Authors: | |
Format: | Article |
Language: | English |
Published: |
American Chemical Society (ACS)
2022
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Online Access: | https://hdl.handle.net/1721.1/141083 |