Di- tert -butyl Phosphonate Route to the Antiviral Drug Tenofovir

Di- tert -butyl Phosphonate Route to the Antiviral Drug Tenofovir

© Di-tert-butyl oxymethyl phosphonates were investigated regarding their suitability for preparing the active pharmaceutical ingredient tenofovir (PMPA). First, an efficient and simple access to the crystalline di-tert-butyl(hydroxymethyl)phosphonate was developed. O-Mesylation gave high yields of...

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Bibliographic Details
Main Authors:	Dietz, Jule-Philipp, Ferenc, Dorota, Jamison, Timothy F, Gupton, B Frank, Opatz, Till
Other Authors:	Massachusetts Institute of Technology. Department of Chemistry
Format:	Article
Language:	English
Published:	American Chemical Society (ACS) 2022
Online Access:	https://hdl.handle.net/1721.1/141083

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