Deep Learning Enables Discovery of a Short Nuclear Targeting Peptide for Efficient Delivery of Antisense Oligomers

Deep Learning Enables Discovery of a Short Nuclear Targeting Peptide for Efficient Delivery of Antisense Oligomers

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Therapeutic macromolecules such as proteins and oligonucleotides can be highly efficacious but are often limited to extracellular targets due to the cell's impermeable membrane. Cell-penetrating peptides (CPPs) are able to deliver such macromolecules into cells, but limited structure-activity r...

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Bibliographic Details
Main Authors: López-Vidal, Eva M., Schissel, Carly K., Mohapatra, Somesh, Bellovoda, Kamela, Wu, Chia-Ling, Wood, Jenna A., Malmberg, Annika B., Loas, Andrei, Gómez-Bombarelli, Rafael, Pentelute, Bradley L.
Other Authors: Massachusetts Institute of Technology. Department of Materials Science and Engineering
Format: Article
Language:English
Published: American Chemical Society (ACS) 2022
Online Access:https://hdl.handle.net/1721.1/141203.2

Internet

https://hdl.handle.net/1721.1/141203.2

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