Automated Flow Synthesis of Peptide–PNA Conjugates
Antisense peptide nucleic acids (PNAs) have yet to translate to the clinic because of poor cellular uptake, limited solubility, and rapid elimination. Cell-penetrating peptides (CPPs) covalently attached to PNAs may facilitate clinical development by improving uptake into cells. We report an efficie...
Main Authors: | , , , , , , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | English |
Published: |
American Chemical Society (ACS)
2022
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Online Access: | https://hdl.handle.net/1721.1/141205 |