Automated Flow Synthesis of Peptide–PNA Conjugates

Automated Flow Synthesis of Peptide–PNA Conjugates

Antisense peptide nucleic acids (PNAs) have yet to translate to the clinic because of poor cellular uptake, limited solubility, and rapid elimination. Cell-penetrating peptides (CPPs) covalently attached to PNAs may facilitate clinical development by improving uptake into cells. We report an efficie...

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Bibliographic Details
Main Authors: Li, Chengxi, Callahan, Alex J, Phadke, Kruttika S, Bellaire, Bryan, Farquhar, Charlotte E, Zhang, Genwei, Schissel, Carly K, Mijalis, Alexander J, Hartrampf, Nina, Loas, Andrei, Verhoeven, David E, Pentelute, Bradley L
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: American Chemical Society (ACS) 2022
Online Access:https://hdl.handle.net/1721.1/141205

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