Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

<jats:title>Abstract</jats:title><jats:p>Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma (GBM) trials. Here, we show that regulatory T (Treg) cells play a key role in GBM resistance to ICBs in experimental gliomas. Targeting glucocorticoid-induced TNFR-r...

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Bibliographic Details
Main Authors: Amoozgar, Zohreh, Kloepper, Jonas, Ren, Jun, Tay, Rong En, Kazer, Samuel W, Kiner, Evgeny, Krishnan, Shanmugarajan, Posada, Jessica M, Ghosh, Mitrajit, Mamessier, Emilie, Wong, Christina, Ferraro, Gino B, Batista, Ana, Wang, Nancy, Badeaux, Mark, Roberge, Sylvie, Xu, Lei, Huang, Peigen, Shalek, Alex K, Fukumura, Dai, Kim, Hye-Jung, Jain, Rakesh K
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2022
Online Access:https://hdl.handle.net/1721.1/141277

Internet

https://hdl.handle.net/1721.1/141277

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