Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma (PDAC), but our understanding of their drivers, stability, and relationship to therapeutic response is limited. To examine these attributes systematically, we profiled metastatic biopsies and matched organoid mod...

Full description

Bibliographic Details
Format:	Article
Language:	English
Published:	Elsevier BV 2022
Online Access:	https://hdl.handle.net/1721.1/141304

Similar Items

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
by: Winter, Peter S., et al.
Published: (2022)

Discovery of microenvironment drivers of cell states, plasticity and drug response
by: Navia, Andrew Warren
Published: (2022)

Shifting the gears of metabolic plasticity to drive cell state transitions in cancer
by: Wu, Zhengwei, et al.
Published: (2021)

ADAM8 as a drug target in pancreatic cancer
by: Schlomann, Uwe, et al.
Published: (2017)

Functionalizing the Tumor Microenvironment with Microfluidics for Anti-cancer Drug Development
by: Shang, Menglin, et al.
Published: (2019)

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism
by: Perera, Rushika M., et al.
Published: (2017)

Implantable microenvironments to attract hematopoietic stem/cancer cells
by: Lee, Jungwoo, et al.
Published: (2013)

Altered exocrine function can drive adipose wasting in early pancreatic cancer
by: Danai, Laura V., et al.
Published: (2020)

The eye as a transplantation site to monitor pancreatic islet cell plasticity
by: Ilegems, Erwin, et al.
Published: (2021)

A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids
by: Griffith, Linda
Published: (2023)

Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors
by: Datta, Rupsa, et al.
Published: (2023)

Intercepting Pancreatic Cancer: Our Dream Teamʼs Resolve to Stop Pancreatic Cancer
by: Jacks, Tyler E
Published: (2020)

Survival of pancreatic cancer cells lacking KRAS function
by: Noll, Elisa M., et al.
Published: (2017)

Tumor extracellular microenvironment responsive carbon dots for enhanced cancer theranostics
by: Feng, Tao
Published: (2017)

Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells
by: Chen, Pan-Yu, et al.
Published: (2020)

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis
by: Jackstadt, Rene, et al.
Published: (2022)

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis
by: Jackstadt, Rene, et al.
Published: (2021)

Amplifying signals in the tumor microenvironment for drug development and diagnostics
by: Martin Alonso, Maria Carmen
Published: (2024)

Expression of the Coxsackie and Adenovirus Receptor (CAR) in pancreatic cancer and normal pancreatic tissue
by: Verbeke, C. S., et al.
Published: (2006)

Mechanistic studies of Gemcitabine-loaded nanoplatforms in resistant pancreatic cancer cells
by: Papa, Anne-Laure, et al.
Published: (2013)

Personalized RNA Medicine for Pancreatic Cancer
by: Gilles, Maud-Emmanuelle, et al.
Published: (2020)

Exploiting vulnerabilities of cancer by targeting nuclear receptors of stromal cells in tumor microenvironment
by: Cheng, Hong Sheng, et al.
Published: (2019)

Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment
by: Truong, Danh, et al.
Published: (2017)

Engineered approaches to querying the microenvironment of cancer metastasis
by: Reticker-Flynn, Nathan Edward
Published: (2016)

Engineered drug delivery nanosystems for tumor microenvironment normalization therapy
by: Yang, Beining, et al.
Published: (2023)

Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma
by: Tian, Chenxi, et al.
Published: (2020)

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors
by: Kellersberger, Katherine A, et al.
Published: (2018)

ASO Research Letter: Trends in Location of Death for Individuals with Pancreatic Cancer in the United States
by: Bajaj, Simar Singh, et al.
Published: (2022)

ASO Research Letter: Trends in Location of Death for Individuals with Pancreatic Cancer in the United States
by: Bajaj, Simar S., et al.
Published: (2022)

Immune responses of human dental pulp stem cells in lipopolysaccharide-induced microenvironment
by: Bindal, Priyadarshini, et al.
Published: (2018)

A Predictive Model for Pancreatic Cancer Diagnosis
by: Xiong, Thomas
Published: (2022)

Study of hypoxia driven pancreatic cancer development
by: Gupta, Nikhil
Published: (2020)

A survey on the awareness of pancreatic cancer in singapore
by: Chong, Jasmine Jia Jun
Published: (2019)

Characterization of the salivary microbiome in patients with pancreatic cancer
by: Torres, Pedro J., et al.
Published: (2016)

Investigating the requirement of KRAS for the maintenance of pancreatic cancer
by: Chen, Pan-Yu
Published: (2016)

Tumor cell migration in complex microenvironments
by: Polacheck, William Joseph, et al.
Published: (2014)

Emergence of a High-Plasticity Cell State during Lung Cancer Evolution
by: Marjanovic, Nemanja Despot, et al.
Published: (2022)

Emergence of a High-Plasticity Cell State during Lung Cancer Evolution
Published: (2021)

Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma
by: Chung, Katherine Minjee, et al.
Published: (2021)

Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells
by: Wu, Yuan Seng, et al.
Published: (2017)