PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis

PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis

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PNC-27, a 32-residue peptide that contains an HDM-2 binding domain and a cell-penetrating peptide (CPP) leader sequence kills cancer, but not normal, cells by binding to HDM-2 associated with the plasma membrane and induces the formation of pores causing tumor cell lysis and necrosis. Conformational...

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Bibliographic Details
Main Authors: Sarafraz-Yazdi, Ehsan, Mumin, Stephen, Cheung, Diana, Fridman, Daniel, Lin, Brian, Wong, Lawrence, Rosal, Ramon, Rudolph, Rebecca, Frenkel, Matthew, Thadi, Anusha, Morano, William F., Bowne, Wilbur B., Pincus, Matthew R., Michl, Josef
Format: Article
Published: Multidisciplinary Digital Publishing Institute 2022
Online Access:https://hdl.handle.net/1721.1/142033

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https://hdl.handle.net/1721.1/142033

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