The widespread IS200/IS605 transposon family encodes diverse programmable RNA-guided endonucleases

The widespread IS200/IS605 transposon family encodes diverse programmable RNA-guided endonucleases

IscB proteins are putative nucleases encoded in a distinct family of IS200/IS605 transposons and are likely ancestors of the RNA-guided endonuclease Cas9, but the functions of IscB and its interactions with any RNA remain uncharacterized. Using evolutionary analysis, RNA sequencing, and biochemical...

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Main Authors: Altae-Tran, Han, Kannan, Soumya, Demircioglu, F Esra, Oshiro, Rachel, Nety, Suchita P, McKay, Luke J, Dlakić, Mensur, Inskeep, William P, Makarova, Kira S, Macrae, Rhiannon K, Koonin, Eugene V, Zhang, Feng
Other Authors: Howard Hughes Medical Institute
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2022
Online Access:https://hdl.handle.net/1721.1/142061

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