Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration
<jats:title>Significance</jats:title> <jats:p>Layer-by-layer nanoparticles (LbL NPs), comprised of a charged core substrate layered sequentially with oppositely charged polyelectrolytes, are a promising class of drug delivery carriers for cancer therapeutics with demonst...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Proceedings of the National Academy of Sciences
2022
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| Online Access: | https://hdl.handle.net/1721.1/142567 |
| _version_ | 1826213309935779840 |
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| author | Kong, Stephanie M Costa, Daniel F Jagielska, Anna Van Vliet, Krystyn J Hammond, Paula T |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT Kong, Stephanie M Costa, Daniel F Jagielska, Anna Van Vliet, Krystyn J Hammond, Paula T |
| author_sort | Kong, Stephanie M |
| collection | MIT |
| description | <jats:title>Significance</jats:title>
<jats:p>Layer-by-layer nanoparticles (LbL NPs), comprised of a charged core substrate layered sequentially with oppositely charged polyelectrolytes, are a promising class of drug delivery carriers for cancer therapeutics with demonstrated success in lowering off-target toxicity and enhancing efficacy. However, little is known about how LbL NP stiffness alters trafficking and delivery. Herein, we report that the stiffness of targeted LbL NPs, comprised of a liposome core and tumor-targeting, polymeric outer layers, can be tuned by altering the mechanical properties of its underlying liposomal core. We also show that these changes have a significant impact on in vivo NP trafficking properties; compliant LbL NPs have longer elimination times, higher organ and tumor accumulation, and higher tumor penetration.</jats:p> |
| first_indexed | 2024-09-23T15:47:01Z |
| format | Article |
| id | mit-1721.1/142567 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:47:01Z |
| publishDate | 2022 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/1425672023-01-11T21:45:22Z Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration Kong, Stephanie M Costa, Daniel F Jagielska, Anna Van Vliet, Krystyn J Hammond, Paula T Koch Institute for Integrative Cancer Research at MIT Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Department of Materials Science and Engineering Massachusetts Institute of Technology. Department of Biological Engineering <jats:title>Significance</jats:title> <jats:p>Layer-by-layer nanoparticles (LbL NPs), comprised of a charged core substrate layered sequentially with oppositely charged polyelectrolytes, are a promising class of drug delivery carriers for cancer therapeutics with demonstrated success in lowering off-target toxicity and enhancing efficacy. However, little is known about how LbL NP stiffness alters trafficking and delivery. Herein, we report that the stiffness of targeted LbL NPs, comprised of a liposome core and tumor-targeting, polymeric outer layers, can be tuned by altering the mechanical properties of its underlying liposomal core. We also show that these changes have a significant impact on in vivo NP trafficking properties; compliant LbL NPs have longer elimination times, higher organ and tumor accumulation, and higher tumor penetration.</jats:p> 2022-05-17T15:31:10Z 2022-05-17T15:31:10Z 2021 2022-05-17T15:10:58Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/142567 Kong, Stephanie M, Costa, Daniel F, Jagielska, Anna, Van Vliet, Krystyn J and Hammond, Paula T. 2021. "Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration." Proceedings of the National Academy of Sciences of the United States of America, 118 (42). en 10.1073/PNAS.2104826118 Proceedings of the National Academy of Sciences of the United States of America Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Proceedings of the National Academy of Sciences PNAS |
| spellingShingle | Kong, Stephanie M Costa, Daniel F Jagielska, Anna Van Vliet, Krystyn J Hammond, Paula T Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration |
| title | Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration |
| title_full | Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration |
| title_fullStr | Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration |
| title_full_unstemmed | Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration |
| title_short | Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration |
| title_sort | stiffness of targeted layer by layer nanoparticles impacts elimination half life tumor accumulation and tumor penetration |
| url | https://hdl.handle.net/1721.1/142567 |
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