Significant Sparse Polygenic Risk Scores across 813 traits in UK Biobank

Significant Sparse Polygenic Risk Scores across 813 traits in UK Biobank

We present a systematic assessment of polygenic risk score (PRS) prediction across more than 1,500 traits using genetic and phenotype data in the UK Biobank. We report 813 sparse PRS models with significant (p < 2.5 x 10−5) incremental predictive performance when compared against the covariate-on...

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Bibliographic Details
Main Authors: Tanigawa, Yosuke, Qian, Junyang, Venkataraman, Guhan, Justesen, Johanne Marie, Li, Ruilin, Tibshirani, Robert, Hastie, Trevor, Rivas, Manuel A.
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Published: Cold Spring Harbor Laboratory 2022
Online Access:https://hdl.handle.net/1721.1/142649

Internet

https://hdl.handle.net/1721.1/142649

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