Selective Permeabilization of Gram-Negative Bacterial Membranes Using Multivalent Peptide Constructs for Antibiotic Sensitization

Selective Permeabilization of Gram-Negative Bacterial Membranes Using Multivalent Peptide Constructs for Antibiotic Sensitization

The drug-impermeable bacterial membrane in Gram-negative pathogens limits antibiotic access to intracellular drug targets. To expand our rapidly waning antibiotic arsenal, one approach is to improve the intracellular delivery of drugs with historically poor accumulation in Gram-negative bacteria. To...

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Bibliographic Details
Main Authors: Chan, Leslie W, Hern, Kelsey E, Ngambenjawong, Chayanon, Lee, Katie, Kwon, Ester J, Hung, Deborah T, Bhatia, Sangeeta N
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: American Chemical Society (ACS) 2022
Online Access:https://hdl.handle.net/1721.1/142859

Internet

https://hdl.handle.net/1721.1/142859

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