Structural Characterization of Plaque Seeded Amyloid-β Fibrils by Magic Angle Spinning NMR
Accumulation of plaques consisting of amyloid fibrils of the peptide amyloid-β (Aβ) in the brain is one of the hallmarks of Alzheimer’s disease (AD). Aβ is prone to polymorphism and the structure of fibrils is sensitive to the conditions under which they are formed. The two dominant forms of Aβ are...
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Massachusetts Institute of Technology
2022
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| Online Access: | https://hdl.handle.net/1721.1/143174 |