Comparison of wild-type and hotspot mutant p53 interactomes: The hunt for mutant-specific binding partners & Investigation and characterization of natural killer cell responses in genetically-engineered mouse models of non-small cell lung cancer
Part 1: The most frequently mutated gene in human cancer is the tumor suppressor gene p53, which is routinely found to have missense mutations at recurrent hotspot residues. Investigations of mutant p53 hotspot variants have suggested novel gain-of-function (GOF) traits, which can be driven through...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2022
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| Online Access: | https://hdl.handle.net/1721.1/143301 |