Biochemical and physiological exploration of the nutrient sensing pathway upstream of mTORC1
The mTORC1 (mechanistic target of rapamycin complex 1) protein kinase controls growth in response to environmental cues. Aberrant mTORC1 activity is linked to numerous diseases including cancer. Understanding the regulation of mTORC1 will facilitate therapeutic developments. Amino acids promote the...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2022
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| Online Access: | https://hdl.handle.net/1721.1/143407 |