Efficient embryonic homozygous gene conversion via RAD51-enhanced interhomolog repair
Searching for factors to improve knockin efficiency for therapeutic applications, biotechnology, and generation of non-human primate models of disease, we found that the strand exchange protein RAD51 can significantly increase Cas9-mediated homozygous knockin in mouse embryos through an interhomolog...
| Principais autores: | , , , , , , , , |
|---|---|
| Outros Autores: | |
| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Elsevier BV
2022
|
| Acesso em linha: | https://hdl.handle.net/1721.1/143451 |