Efficient embryonic homozygous gene conversion via RAD51-enhanced interhomolog repair

Efficient embryonic homozygous gene conversion via RAD51-enhanced interhomolog repair

Searching for factors to improve knockin efficiency for therapeutic applications, biotechnology, and generation of non-human primate models of disease, we found that the strand exchange protein RAD51 can significantly increase Cas9-mediated homozygous knockin in mouse embryos through an interhomolog...

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Bibliographic Details
Main Authors: Wilde, Jonathan J, Aida, Tomomi, del Rosario, Ricardo CH, Kaiser, Tobias, Qi, Peimin, Wienisch, Martin, Zhang, Qiangge, Colvin, Steven, Feng, Guoping
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: Elsevier BV 2022
Online Access:https://hdl.handle.net/1721.1/143451

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https://hdl.handle.net/1721.1/143451

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