Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial Function

Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial Function

BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is among the most common cancer types worldwide, yet patients with HCC have limited treatment options. There is an urgent need to identify drug targets that specifically inhibit the growth of HCC cells. APPROACH AND RESULTS: We used a CRISPR librar...

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Bibliographic Details
Main Authors: Jiang, Tingting, Sánchez-Rivera, Francisco J, Soto-Feliciano, Yadira M, Yang, Qiyuan, Song, Chun-Qing, Bhuatkar, Arjun, Haynes, Cole M, Hemann, Michael T, Xue, Wen
Other Authors: Whitehead Institute for Biomedical Research
Format: Article
Language:English
Published: Wiley 2022
Online Access:https://hdl.handle.net/1721.1/143563

Internet

https://hdl.handle.net/1721.1/143563

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