BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1

BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1

<jats:p> BACE-1 is required for generating β-amyloid (Aβ) peptides in Alzheimer’s disease (AD). Here, we report that microglial BACE-1 regulates the transition of homeostatic to stage 1 disease-associated microglia (DAM-1) signature. BACE-1 deficiency elevated levels of transcript...

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Bibliographic Details
Main Authors: Singh, Neeraj, Benoit, Marc R, Zhou, John, Das, Brati, Davila-Velderrain, Jose, Kellis, Manolis, Tsai, Li-Huei, Hu, Xiangyou, Yan, Riqiang
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2022
Online Access:https://hdl.handle.net/1721.1/143715

Internet

https://hdl.handle.net/1721.1/143715

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