Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease

Neurons are highly susceptible to DNA damage accumulation due to their large energy requirements, elevated transcriptional activity, and long lifespan. While newer research has shown that DNA breaks and mutations may facilitate neuron diversity during development and neuronal function throughout lif...

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Bibliographic Details
Main Authors: Welch, Gwyneth, Tsai, Li‐Huei
Other Authors: Picower Institute for Learning and Memory
Format: Article
Language:English
Published: EMBO 2022
Online Access:https://hdl.handle.net/1721.1/144149