Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease
Neurons are highly susceptible to DNA damage accumulation due to their large energy requirements, elevated transcriptional activity, and long lifespan. While newer research has shown that DNA breaks and mutations may facilitate neuron diversity during development and neuronal function throughout lif...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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EMBO
2022
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| Online Access: | https://hdl.handle.net/1721.1/144149 |
| _version_ | 1826197844446412800 |
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| author | Welch, Gwyneth Tsai, Li‐Huei |
| author2 | Picower Institute for Learning and Memory |
| author_facet | Picower Institute for Learning and Memory Welch, Gwyneth Tsai, Li‐Huei |
| author_sort | Welch, Gwyneth |
| collection | MIT |
| description | Neurons are highly susceptible to DNA damage accumulation due to their large energy requirements, elevated transcriptional activity, and long lifespan. While newer research has shown that DNA breaks and mutations may facilitate neuron diversity during development and neuronal function throughout life, a wealth of evidence indicates deficient DNA damage repair underlies many neurological disorders, especially age-associated neurodegenerative diseases. Recently, efforts to clarify the molecular link between DNA damage and neurodegeneration have improved our understanding of how the genomic location of DNA damage and defunct repair proteins impact neuron health. Additionally, work establishing a role for senescence in the aging and diseased brain reveals DNA damage may play a central role in neuroinflammation associated with neurodegenerative disease. |
| first_indexed | 2024-09-23T10:54:22Z |
| format | Article |
| id | mit-1721.1/144149 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:54:22Z |
| publishDate | 2022 |
| publisher | EMBO |
| record_format | dspace |
| spelling | mit-1721.1/1441492023-04-14T19:24:19Z Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease Welch, Gwyneth Tsai, Li‐Huei Picower Institute for Learning and Memory Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Neurons are highly susceptible to DNA damage accumulation due to their large energy requirements, elevated transcriptional activity, and long lifespan. While newer research has shown that DNA breaks and mutations may facilitate neuron diversity during development and neuronal function throughout life, a wealth of evidence indicates deficient DNA damage repair underlies many neurological disorders, especially age-associated neurodegenerative diseases. Recently, efforts to clarify the molecular link between DNA damage and neurodegeneration have improved our understanding of how the genomic location of DNA damage and defunct repair proteins impact neuron health. Additionally, work establishing a role for senescence in the aging and diseased brain reveals DNA damage may play a central role in neuroinflammation associated with neurodegenerative disease. 2022-07-29T18:05:15Z 2022-07-29T18:05:15Z 2022-06-07 2022-07-29T18:00:22Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/144149 Welch, Gwyneth and Tsai, Li‐Huei. 2022. "Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease." EMBO reports, 23 (6). en 10.15252/embr.202154217 EMBO reports Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf EMBO EMBO Press |
| spellingShingle | Welch, Gwyneth Tsai, Li‐Huei Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease |
| title | Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease |
| title_full | Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease |
| title_fullStr | Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease |
| title_full_unstemmed | Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease |
| title_short | Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease |
| title_sort | mechanisms of dna damage mediated neurotoxicity in neurodegenerative disease |
| url | https://hdl.handle.net/1721.1/144149 |
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