Tertiary motifs as building blocks for the design of protein‐binding peptides

Despite advances in protein engineering, the de novo design of small proteins or peptides that bind to a desired target remains a difficult task. Most computational methods search for binder structures in a library of candidate scaffolds, which can lead to designs with poor target complementarity an...

Full description

Bibliographic Details
Main Authors: Swanson, Sebastian, Sivaraman, Venkatesh, Grigoryan, Gevorg, Keating, Amy E
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Wiley 2022
Online Access:https://hdl.handle.net/1721.1/144152