Integration of Spatial Transcriptomics with Chromatin Images Using Graph-Based Autoencoder Identifies Joint Biomarkers for Alzheimer’s Disease
Tissue development and disease lead to changes in cellular organization, nuclear morphology, as well as gene expression. Spatial transcriptomic technologies, such as STARmap and 10x Visium, allow the joint measurement of these different modalities in whole tissue sections.1,2 However, methods for jo...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2022
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| Online Access: | https://hdl.handle.net/1721.1/144496 |