Mechanical and Biologic Impact of Dynamic Loading on Bovine and Human Models of Osteoarthritis
Both dexamethasone (Dex) and Insulin-like growth factor 1 (IGF-1) have shown promise as disease-modifying therapeutics for osteoarthritis (OA), a disease characterized by cartilage degradation. Additionally, dynamic loading has been demonstrated to affect chondrocyte metabolic activity, with mechani...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2022
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| Online Access: | https://hdl.handle.net/1721.1/144649 |