Regulation of Presynaptic Ca²⁺ Channel Abundance at Active Zones Through a Balance of Delivery and Turnover
Voltage-gated Ca²⁺ channels (VGCCs) mediate Ca²⁺ influx to trigger neurotransmitter release at specialized presynaptic sites termed active zones (AZs). The abundance of VGCCs at AZs regulates neurotransmitter release probability (Pᵣ), a key presynaptic determinant of synaptic strength. Although bios...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2022
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| Online Access: | https://hdl.handle.net/1721.1/144830 |