Structural Principles of Substrate Recognition and Unfolding by the ClpAP and ClpXP AAA+ Proteases
Protein degradation is a key regulatory mechanism that controls protein homeostasis in all cells. Found in all domains of life, proteases of the AAA+ (ATPases associated with diverse cellular activities) superfamily perform targeted protein degradation of specific substrates. All AAA+ proteases cons...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2022
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| Online Access: | https://hdl.handle.net/1721.1/144898 |