Continuous Directed Evolution in Mammalian Cells

Directed evolution is a powerful methodology for the creation of new biomolecules with user-desired functions. Most directed evolution experiments are performed in vitro, in bacteria, or in yeast, even when the evolved biomolecule is intended to function in mammalian cells. As a result, the function...

Full description

Bibliographic Details
Main Author: Hendel, Samuel Joseph
Other Authors: Shoulders, Matthew
Format: Thesis
Published: Massachusetts Institute of Technology 2022
Online Access:https://hdl.handle.net/1721.1/145089