Functional and Pathological States of the Protein Tau Investigated with Solid-State NMR

The microtubule-associated protein tau is expressed at high levels in human brain, and its binding and stabilization of microtubules is thought to play key roles in the maintenance of neurons. However, tau is found to pathologically aggregate into specific fibrillar structures in a number of neurode...

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Bibliographic Details
Main Author: Dregni, Aurelio J.
Other Authors: Hong, Mei
Format: Thesis
Published: Massachusetts Institute of Technology 2022
Online Access:https://hdl.handle.net/1721.1/145173
https://orcid.org/ 0000-0003-3422-4734