Steric accessibility of the N-terminus improves the titer and quality of recombinant proteins secreted from Komagataella phaffii

Steric accessibility of the N-terminus improves the titer and quality of recombinant proteins secreted from Komagataella phaffii

Abstract Background Komagataella phaffii is a commonly used alternative host for manufacturing therapeutic proteins, in part because of its ability to secrete recombinant proteins into the extracellular space. Incorrect processing of secreted protein...

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Bibliographic Details
Main Authors: Dalvie, Neil C., Naranjo, Christopher A., Rodriguez-Aponte, Sergio A., Johnston, Ryan S., Christopher Love, J.
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: BioMed Central 2022
Online Access:https://hdl.handle.net/1721.1/145353

Internet

https://hdl.handle.net/1721.1/145353

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