Measuring the tolerance of the genetic code to altered codon size

<jats:p>Translation using four-base codons occurs in both natural and synthetic systems. What constraints contributed to the universal adoption of a triplet codon, rather than quadruplet codon, genetic code? Here, we investigate the tolerance of the <jats:italic>Escherichia coli</jats...

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Bibliographic Details
Main Authors: DeBenedictis, Erika Alden, Söll, Dieter, Esvelt, Kevin M
Other Authors: Program in Media Arts and Sciences (Massachusetts Institute of Technology)
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd 2022
Online Access:https://hdl.handle.net/1721.1/146067