Regulation of amino acid transport across the lysosomal surface by the mTORC1 pathway
Multicellular eukaryotes readily adjust their growth in response to environmental cues. A central nutrient sensing pathway crucial for this process requires the mechanistic target of rapamycin complex 1 (mTORC1), which integrates various inputs such as amino acids, growth factor signaling and energy...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2022
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| Online Access: | https://hdl.handle.net/1721.1/146299 |