MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position

MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position

<jats:p>MicroRNAs (miRNAs), in association with Argonaute (AGO) proteins, direct repression by pairing to sites within mRNAs. Compared to pairing preferences of the miRNA seed region (nucleotides 2–8), preferences of the miRNA 3′ region are poorly understood, due to the sparsity of measured af...

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Bibliographic Details
Main Authors: McGeary, Sean E, Bisaria, Namita, Pham, Thy M, Wang, Peter Y, Bartel, David P
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd 2022
Online Access:https://hdl.handle.net/1721.1/146764

Internet

https://hdl.handle.net/1721.1/146764

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