Multiple mechanisms for overcoming lethal over‐initiation of DNA replication

DNA replication is highly regulated and primarily controlled at the step of initiation. In bacteria, the replication initiator DnaA and the origin of replication oriC are the primary targets of regulation. Perturbations that increase or decrease replication initiation can cause a decrease in cell fi...

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Bibliographic Details
Main Authors: Anderson, Mary E, Smith, Janet L, Grossman, Alan D
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Wiley 2022
Online Access:https://hdl.handle.net/1721.1/146802