Backbone-Anchoring, Solid-Phase Synthesis Strategy To Access a Library of Peptidouridine-Containing Small Molecules

Nucleoside diphosphate sugar (NDP-sugar) substrates provide the inspiration for nucleoside analogue inhibitor scaffolds. By employing solid-phase synthesis, we provide a method to access a library of peptidouridine inhibitors with both minimal compound handling and purification steps. Specifically,...

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Bibliographic Details
Main Authors: Arbour, Christine A, Imperiali, Barbara
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: American Chemical Society (ACS) 2022
Online Access:https://hdl.handle.net/1721.1/146812