Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes

Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes

In tumors, a subset of CD8+ T cells expressing the transcription factor TCF-1 drives the response to immune checkpoint blockade. We examined the mechanisms that maintain these cells in an autochthonous model of lung adenocarcinoma. Longitudinal sampling and single-cell sequencing of tumor-antigen sp...

Full description

Bibliographic Details
Main Authors: Schenkel, Jason M, Herbst, Rebecca H, Canner, David, Li, Amy, Hillman, Michelle, Shanahan, Sean-Luc, Gibbons, Grace, Smith, Olivia C, Kim, Jonathan Y, Westcott, Peter, Hwang, William L, Freed-Pastor, William A, Eng, George, Cuoco, Michael S, Rogers, Patricia, Park, Jin K, Burger, Megan L, Rozenblatt-Rosen, Orit, Cong, Le, Pauken, Kristen E, Regev, Aviv, Jacks, Tyler
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2022
Online Access:https://hdl.handle.net/1721.1/146817

Internet

https://hdl.handle.net/1721.1/146817

Similar Items