The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance

The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance

<jats:title>Abstract</jats:title><jats:p>Insulin receptor (IR) signaling is central to normal metabolic control and is dysregulated in metabolic diseases such as type 2 diabetes. We report here that IR is incorporated into dynamic clusters at the plasma membrane, in the cytoplasm a...

Full description

Bibliographic Details
Main Authors: Dall’Agnese, Alessandra, Platt, Jesse M, Zheng, Ming M, Friesen, Max, Dall’Agnese, Giuseppe, Blaise, Alyssa M, Spinelli, Jessica B, Henninger, Jonathan E, Tevonian, Erin N, Hannett, Nancy M, Lazaris, Charalampos, Drescher, Hannah K, Bartsch, Lea M, Kilgore, Henry R, Jaenisch, Rudolf, Griffith, Linda G, Cisse, Ibrahim I, Jeppesen, Jacob F, Lee, Tong I, Young, Richard A
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2022
Online Access:https://hdl.handle.net/1721.1/146838

Internet

https://hdl.handle.net/1721.1/146838

Similar Items