Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

<jats:title>Abstract</jats:title><jats:p>Karyotype alterations have emerged as on-target complications from CRISPR-Cas9 genome editing. However, the events that lead to these karyotypic changes in embryos after Cas9-treatment remain unknown. Here, using imaging and single-cell geno...

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Bibliographic Details
Main Authors: Papathanasiou, Stamatis, Markoulaki, Styliani, Blaine, Logan J, Leibowitz, Mitchell L, Zhang, Cheng-Zhong, Jaenisch, Rudolf, Pellman, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2022
Online Access:https://hdl.handle.net/1721.1/146846

Internet

https://hdl.handle.net/1721.1/146846

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