E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6

E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6

<jats:p> Multiciliogenesis requires both nuclear and cytoplasmic functions of the E2F4 transcription factor. Here we identify a domain in E2F4 that interacts with two key components of the cytoplasmic centriole replication machinery, Deup1 and SAS6, and is sufficient to mediate E2F4’s cytoplas...

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Bibliographic Details
Main Authors: Hazan, Renin, Mori, Munemasa, Danielian, Paul S, Guen, Vincent J, Rubin, Seth M, Cardoso, Wellington V, Lees, Jacqueline A
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: American Society for Cell Biology (ASCB) 2022
Online Access:https://hdl.handle.net/1721.1/146881

Internet

https://hdl.handle.net/1721.1/146881

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