E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6
<jats:p> Multiciliogenesis requires both nuclear and cytoplasmic functions of the E2F4 transcription factor. Here we identify a domain in E2F4 that interacts with two key components of the cytoplasmic centriole replication machinery, Deup1 and SAS6, and is sufficient to mediate E2F4’s cytoplas...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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American Society for Cell Biology (ASCB)
2022
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| Online Access: | https://hdl.handle.net/1721.1/146881 |
| _version_ | 1826191358157651968 |
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| author | Hazan, Renin Mori, Munemasa Danielian, Paul S Guen, Vincent J Rubin, Seth M Cardoso, Wellington V Lees, Jacqueline A |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Hazan, Renin Mori, Munemasa Danielian, Paul S Guen, Vincent J Rubin, Seth M Cardoso, Wellington V Lees, Jacqueline A |
| author_sort | Hazan, Renin |
| collection | MIT |
| description | <jats:p> Multiciliogenesis requires both nuclear and cytoplasmic functions of the E2F4 transcription factor. Here we identify a domain in E2F4 that interacts with two key components of the cytoplasmic centriole replication machinery, Deup1 and SAS6, and is sufficient to mediate E2F4’s cytoplasmic role in multiciliogenesis. </jats:p> |
| first_indexed | 2024-09-23T08:55:00Z |
| format | Article |
| id | mit-1721.1/146881 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:55:00Z |
| publishDate | 2022 |
| publisher | American Society for Cell Biology (ASCB) |
| record_format | dspace |
| spelling | mit-1721.1/1468812022-12-15T03:46:55Z E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6 Hazan, Renin Mori, Munemasa Danielian, Paul S Guen, Vincent J Rubin, Seth M Cardoso, Wellington V Lees, Jacqueline A Massachusetts Institute of Technology. Department of Biology <jats:p> Multiciliogenesis requires both nuclear and cytoplasmic functions of the E2F4 transcription factor. Here we identify a domain in E2F4 that interacts with two key components of the cytoplasmic centriole replication machinery, Deup1 and SAS6, and is sufficient to mediate E2F4’s cytoplasmic role in multiciliogenesis. </jats:p> 2022-12-14T18:03:17Z 2022-12-14T18:03:17Z 2021 2022-12-14T17:59:40Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/146881 Hazan, Renin, Mori, Munemasa, Danielian, Paul S, Guen, Vincent J, Rubin, Seth M et al. 2021. "E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6." Molecular Biology of the Cell, 32 (20). en 10.1091/MBC.E21-01-0039 Molecular Biology of the Cell Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf American Society for Cell Biology (ASCB) American Society for Cell Biology |
| spellingShingle | Hazan, Renin Mori, Munemasa Danielian, Paul S Guen, Vincent J Rubin, Seth M Cardoso, Wellington V Lees, Jacqueline A E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6 |
| title | E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6 |
| title_full | E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6 |
| title_fullStr | E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6 |
| title_full_unstemmed | E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6 |
| title_short | E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6 |
| title_sort | e2f4 s cytoplasmic role in multiciliogenesis is mediated via an n terminal domain that binds two components of the centriole replication machinery deup1 and sas6 |
| url | https://hdl.handle.net/1721.1/146881 |
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