FtsH degrades kinetically stable dimers of cyclopropane fatty acid synthase via an internal degron

Targeted protein degradation plays important roles in stress responses in all cells. In E. coli, the membrane-bound AAA+ FtsH protease degrades cytoplasmic and membrane proteins. Here, we demonstrate that FtsH degrades cyclopropane fatty acid (CFA) synthase, whose synthesis is induced upon nutrient...

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Bibliographic Details
Main Authors: Hari, Sanjay B, Morehouse, Juhee P, Baker, Tania A, Sauer, Robert T
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Wiley 2023
Online Access:https://hdl.handle.net/1721.1/146956