Methionine synthase is essential for cancer cell proliferation in physiological folate environments

Methionine synthase is essential for cancer cell proliferation in physiological folate environments

Folate metabolism can be an effective target for cancer treatment. However, standard cell culture conditions utilize folic acid, a non-physiological folate source for most tissues. We find that the enzyme that couples folate and methionine metabolic cycles, methionine synthase, is required for cance...

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Bibliographic Details
Main Authors: Sullivan, Mark R, Darnell, Alicia M, Reilly, Montana F, Kunchok, Tenzin, Joesch-Cohen, Lena, Rosenberg, Daniel, Ali, Ahmed, Rees, Matthew G, Roth, Jennifer A, Lewis, Caroline A, Vander Heiden, Matthew G
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2023
Online Access:https://hdl.handle.net/1721.1/146998

Internet

https://hdl.handle.net/1721.1/146998

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