Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality

Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality

β-Lactam antibiotics disrupt the assembly of peptidoglycan (PG) within the bacterial cell wall by inhibiting the enzymatic activity of penicillin-binding proteins (PBPs). It was recently shown that β-lactam treatment initializes a futile cycle of PG synthesis and degradation, highlighting major gaps...

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Bibliographic Details
Main Authors: Lobritz, Michael A, Andrews, Ian W, Braff, Dana, Porter, Caroline BM, Gutierrez, Arnaud, Furuta, Yoshikazu, Cortes, Louis BG, Ferrante, Thomas, Bening, Sarah C, Wong, Felix, Gruber, Charley, Bakerlee, Christopher W, Lambert, Guillaume, Walker, Graham C, Dwyer, Daniel J, Collins, James J
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2023
Online Access:https://hdl.handle.net/1721.1/147003

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https://hdl.handle.net/1721.1/147003

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