Nucleotide imbalance decouples cell growth from cell proliferation
<jats:title>Abstract</jats:title><jats:p>Nucleotide metabolism supports RNA synthesis and DNA replication to enable cell growth and division. Nucleotide depletion can inhibit cell growth and proliferation, but how cells sense and respond to changes in the relative levels of individ...
Main Authors: | Diehl, Frances F, Miettinen, Teemu P, Elbashir, Ryan, Nabel, Christopher S, Darnell, Alicia M, Do, Brian T, Manalis, Scott R, Lewis, Caroline A, Vander Heiden, Matthew G |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media LLC
2023
|
Online Access: | https://hdl.handle.net/1721.1/147019 |
Similar Items
-
Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation
by: Diehl, Frances F., et al.
Published: (2020) -
Mass measurements during lymphocytic leukemia cell polyploidization decouple cell cycle- and cell size-dependent growth
by: Mu, Luye, et al.
Published: (2021) -
Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation
by: Lunt, Sophia Y., et al.
Published: (2016) -
Mass measurements during lymphocytic leukemia cell polyploidization decouple cell cycle- and cell size-dependent growth
by: Mu, Luye, et al.
Published: (2021) -
Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease
by: Fan Jia, et al.
Published: (2020-02-01)