Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles

Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles

<jats:p>A novel macrocyclic peptide strategy utilizing a glutamic acid analog that can work as an alkylated histidine replacement.</jats:p>

Bibliographic Details
Main Authors: Hymel, David, Tsuji, Kohei, Grant, Robert A, Chingle, Ramesh M, Kunciw, Dominique L, Yaffe, Michael B, Burke, Terrence R
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Royal Society of Chemistry (RSC) 2023
Online Access:https://hdl.handle.net/1721.1/147021

Internet

https://hdl.handle.net/1721.1/147021

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