Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles
<jats:p>A novel macrocyclic peptide strategy utilizing a glutamic acid analog that can work as an alkylated histidine replacement.</jats:p>
Main Authors: | Hymel, David, Tsuji, Kohei, Grant, Robert A, Chingle, Ramesh M, Kunciw, Dominique L, Yaffe, Michael B, Burke, Terrence R |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | English |
Published: |
Royal Society of Chemistry (RSC)
2023
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Online Access: | https://hdl.handle.net/1721.1/147021 |
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