A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

T cells engineered to express chimeric antigen receptors (CARs) targeting CD19 have produced impressive outcomes for the treatment of B cell malignancies, but different products vary in kinetics, persistence, and toxicity profiles based on the co-stimulatory domains included in the CAR. In this stud...

Full description

Bibliographic Details
Main Authors: Boroughs, Angela C, Larson, Rebecca C, Marjanovic, Nemanja D, Gosik, Kirk, Castano, Ana P, Porter, Caroline BM, Lorrey, Selena J, Ashenberg, Orr, Jerby, Livnat, Hofree, Matan, Smith-Rosario, Gabriela, Morris, Robert, Gould, Joshua, Riley, Lauren S, Berger, Trisha R, Riesenfeld, Samantha J, Rozenblatt-Rosen, Orit, Choi, Bryan D, Regev, Aviv, Maus, Marcela V
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2023
Online Access:https://hdl.handle.net/1721.1/147057

Internet

https://hdl.handle.net/1721.1/147057

Similar Items