Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function

Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function

<jats:p>Understanding gene function and regulation in homeostasis and disease requires knowledge of the cellular and tissue contexts in which genes are expressed. Here, we applied four single-nucleus RNA sequencing methods to eight diverse, archived, frozen tissue types from 16 donors and 25 s...

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Main Authors: Eraslan, Gökcen, Drokhlyansky, Eugene, Anand, Shankara, Fiskin, Evgenij, Subramanian, Ayshwarya, Slyper, Michal, Wang, Jiali, Van Wittenberghe, Nicholas, Rouhana, John M, Waldman, Julia, Ashenberg, Orr, Lek, Monkol, Dionne, Danielle, Win, Thet Su, Cuoco, Michael S, Kuksenko, Olena, Tsankov, Alexander M, Branton, Philip A, Marshall, Jamie L, Greka, Anna, Getz, Gad, Segrè, Ayellet V, Aguet, François, Rozenblatt-Rosen, Orit, Ardlie, Kristin G, Regev, Aviv
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2023
Online Access:https://hdl.handle.net/1721.1/147069

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https://hdl.handle.net/1721.1/147069

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