The Roles of the Mcm2-7 Tails in Replication Initiation

DNA replication is complex biological reaction that spans two stages of the eukaryotic cell cycle. In G1 phase, preparation for replication begins when two copies of the replicative helicase, the Mcm2-7 complex, are loaded onto DNA. However, these helicases are loaded in an inactive state, and are n...

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Bibliographic Details
Main Author: Gangaramani, Paritosh
Other Authors: Bell, Stephen P.
Format: Thesis
Published: Massachusetts Institute of Technology 2023
Online Access:https://hdl.handle.net/1721.1/147266
https://orcid.org/0000-0002-4893-8167