The sound of silence: Transgene silencing in mammalian cell engineering

To elucidate principles operating in native biological systems and to develop novel biotechnologies, synthetic biology aims to build and integrate synthetic gene circuits within native transcriptional networks. The utility of synthetic gene circuits for cell engineering relies on the ability to cont...

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Bibliographic Details
Main Authors: Cabrera, Alan, Edelstein, Hailey I, Glykofrydis, Fokion, Love, Kasey S, Palacios, Sebastian, Tycko, Josh, Zhang, Meng, Lensch, Sarah, Shields, Cara E, Livingston, Mark, Weiss, Ron, Zhao, Huimin, Haynes, Karmella A, Morsut, Leonardo, Chen, Yvonne Y, Khalil, Ahmad S, Wong, Wilson W, Collins, James J, Rosser, Susan J, Polizzi, Karen, Elowitz, Michael B, Fussenegger, Martin, Hilton, Isaac B, Leonard, Joshua N, Bintu, Lacramioara, Galloway, Kate E, Deans, Tara L
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Elsevier BV 2023
Online Access:https://hdl.handle.net/1721.1/147792